Cell cycle
| PAG Title | Cell cycle |
| PAG ID | WAG000195 |
| Type | P |
| Source Link |  KEGG |
| Publication Reference | NA |
| PAG Description | Mitotic cell cycle progression is accomplished through a reproducible sequence of events, D replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kises (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and ictivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. |
| Species | Homo sapiens |
| nCoCo Score | 7,076 |
| Base PAG ID | WAG000195 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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